Eastern Neck National Wildlife Refuge is located on the Eastern Shore in Maryland, about 6 miles south of Rock Hall.
From Maryland's western shore (Annapolis, MD): Take U.S. Rt. 50/301 East across the Chesapeake Bay Bridge ($2.50 toll). Continue on Rt. 301 North after 50 and 301 split Exit Rt. 301 North onto Rt. 213 North towards Chestertown. Continue on Rt. 213 North into Chestertown (see directions below).
From points north: Take Rt. 213 South to Chestertown OR Take Rt. 301 South to Rt. 290 (Galena/Sassafras). Follow Rt. 290 South to Galena, MD. Continue straight through light onto Rt. 213 South Take Rt. 213 South to Chestertown (see directions below).
From points south along the Eastern Shore: Take Rt. 50 West to Rt. 301 North. Take Rt. 301 North a few miles to Rt. 213 North. Take Rt. 213 North into Chestertown (see directions below).
From Chestertown, MD: In Chestertown, turn from Rt. 213 onto Rt. 291 (also marked "to Rt. 20"). At the T-intersection, turn right onto Rt. 20 South toward Rock Hall. Follow Rt. 20 South for 12 miles to Rock Hall. At blinking red light, turn left onto Rt. 445. Follow Rt. 445 about 8 miles out of Rock Hall to the refuge entrance bridge.