Spruce Knob-Seneca Rocks National Recreation Area is located in eastern West Virginia.
From I-81 (East or South): Follow I-81 to U.S. Route 33 West at Harrisonburg. Follow route 33 for about 53 miles to the junction with WV Route 28. The Seneca Rocks Discover Center is nearby.
From I-79 (West): Take the WV Route 20 exit (exit number 115) towards Stonewood/Nutter Fort. Turn left onto WV-20. Stay straight to go onto WV-20. Follow it for 21 miles. Turn left onto US Route 33 and follow to the junction with WV Route 28. The Seneca Rocks Discover Center is nearby.
From I-48 (North): Take 220 South to US Route 33. Turn west onto US-33 and proceed to the junction with WV Route 28. The Seneca Rocks Discover Center is nearby.