Recreational boat traffic on the river is steady and tends to originate in the Seaford area and head south. Two boat launch access sites – Phillips Landing and Seaford – provide year-round direct access to the Nanticoke River. Each site has multiple ramps, portable toilets, and parking. A single, soft landing is located at the Seaford Canoe Launch. A floating ramp for access and temporary dockage is available at the Seaford River Walk. Fishing access is located at the River Walk and River Park (both in Seaford), and Phillips Landing. Picnic facilities are found at River Park, Phillips Landing and Blades Marina. Shared-use trails for hikers and equestrians are located in the Nanticoke Wildlife Area.
Newly-renovated and pedestrian-friendly, shops, business services, the Seaford Museum, and historic sites are located in downtown Seaford, just one block from the River Walk on High Street. Across the river from Seaford is the small town of Blades, host to the Nanticoke River Marina. This is the only recreational marina on this stretch of the river and is open Thursday through Sunday from 8am to 5pm during boating season, and currently offers limited services to the general public.